Spirer Z, Hauzer G, Zakuth V, Diamant S, Golander A
J Clin Lab Immunol. 1981 Sep;6(2):111-3.
The immune functions were evaluated in 30 children, aged one year to 9 8/12 years, who had suffered during their early infancy from protein-calorie malnutrition (PCM) as the result of intractable diarrhea. Twelve healthy children matched for age and sex served as controls. All 42 children responded normally to intradermal injections of tuberculin and candida antigens. The reduction of nitrous blue tetrazolium (NBT) by the polymorphonuclear leucocytes (PMN) was normal. Apart from the lower concentrations of IgM in the post-PCM group--145 +/- 67 mg % as compared to 212.8 +/- 46 mg % (p less than 0.005)--no differences were noted in the other serum immunoglobulin and complement levels. The response to phytohaemagglutinins (PHA) in two different concentrations was significantly enhanced in the post-PCM group (p less than 0.05). The per cent of T cells in both groups was normal. The results of this study indicate that most immunologic parameters return to normal after a healthy nutritional status has been achieved, with the exception of some abnormalities in IgM production and lymphocyte reactivity to PHA. These need further investigation.
对30名年龄在1岁至9岁8个月的儿童的免疫功能进行了评估，这些儿童在婴儿早期因顽固性腹泻而患有蛋白质 - 热量营养不良（PCM）。12名年龄和性别匹配的健康儿童作为对照。所有42名儿童对结核菌素和念珠菌抗原的皮内注射反应正常。多形核白细胞（PMN）对亚硝基蓝四氮唑（NBT）的还原正常。除了PCM后组中IgM浓度较低（145±67mg%，而对照组为212.8±46mg%，p<0.005）外，其他血清免疫球蛋白和补体水平没有差异。PCM后组对两种不同浓度的植物血凝素（PHA）的反应显著增强（p<0.05）。两组中T细胞的百分比正常。本研究结果表明，在达到健康营养状态后，大多数免疫参数恢复正常，但IgM产生和淋巴细胞对PHA的反应存在一些异常除外。这些需要进一步研究。
