Sarkar S, Shah P N, Bagli N P
Neoplasma. 1981;28(4):457-61.
The effect of a crude protein fraction from human urine having gonadotropin inhibitory activity (GGIM) was observed on the growth of 7,12-dimethylbenz(a)anthracene induced mammary tumors in Holtzman rat. Results show that while in 12 out 13 tumors, tumor growth was retarded/regressed following 2--4 weeks of CGIM treatment, tumor growth in control rats was unabated. However, no positive correlation with hormone dependency and tumor regression could be established. Further, this crude anti LH material was found to be non-toxic to tumor cells in vitro.
观察了具有促性腺激素抑制活性的人尿粗蛋白组分（GGIM）对7,12-二甲基苯并（a）蒽诱导的霍尔兹曼大鼠乳腺肿瘤生长的影响。结果显示，在13个肿瘤中有12个，经GGIM处理2 - 4周后肿瘤生长受到抑制/消退，而对照大鼠的肿瘤生长未减弱。然而，无法确定其与激素依赖性和肿瘤消退之间的正相关关系。此外，发现这种粗制的抗促黄体生成素物质在体外对肿瘤细胞无毒。
