Toru M, Mataga N, Takashima M, Nishikawa T
Psychopharmacology (Berl). 1981;74(4):316-20. doi: 10.1007/BF00432738.
After a drug-free period of 1 week following 2 weeks of haloperidol treatment, the increased response of striatal 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) to a challenge dose of haloperidol was significantly reduced. Tolerance to this effect was not, however, seen in the mesolimbic system. Pretreatment of the rats with methamphetamine (MAP) for 8 days prior to chronic haloperidol significantly enhanced the DOPAC and HVA increase produced by the challenge with haloperidol in both brain areas. The reduced response of striatal DOPAC or HVA after chronic haloperidol was prevented by pretreatment with MAP. The data suggest that the long-term dopamine receptor stimulation induced by MAP may antagonize the tolerance produced by chronic haloperidol treatment.
在接受2周氟哌啶醇治疗后经过1周的停药期，纹状体中3,4-二羟基苯乙酸（DOPAC）和高香草酸（HVA）对氟哌啶醇激发剂量的反应增强显著降低。然而，在中脑边缘系统中未观察到对这种效应的耐受性。在慢性氟哌啶醇治疗前8天用甲基苯丙胺（MAP）预处理大鼠，可显著增强两个脑区中氟哌啶醇激发所产生的DOPAC和HVA增加。MAP预处理可防止慢性氟哌啶醇治疗后纹状体DOPAC或HVA反应降低。数据表明，MAP诱导的长期多巴胺受体刺激可能拮抗慢性氟哌啶醇治疗产生的耐受性。
