Nomura Y, Oki K, Segawa T
J Pharmacobiodyn. 1980 Feb;3(2):111-6. doi: 10.1248/bpb1978.3.111.
The mesolimbic-striatal content of 3,4-dihydroxyphenylacetic acid (DOPAC) gradually increased with age in the developing rat. An intraperitoneal (i.p.) injection of apomorphine (2 mg/kg) or haloperidol (0.1 mg/kg) caused a significant change in the DOPAC content on day 20 and day 70, but not on day 7. However, a higher dose of apomorphine (10 mg/kg, i.p.) or haloperidol (5 mg/kg, i.p.) as well as that of alpha-flupenthixol (0.5 mg/kg, i.p.) significantly affected the mesolimbic-striatal content of DOPAC in 7-day-old rats. In 24-day-old rats subchronically treated with haloperidol (1 mg/kg to 10 mg/kg for 10 days, s.c.), apomorphine (2 mg/kg, i.p.) produced a significant reduction in the mesolimbic content of DOPAC at the withdrawal stage of the drug, but not in control rats. It is suggested that mesolimbic-striatal dopamine (DA) receptors which are not fully sensitive to DA agonists and antagonists on day 7 reach functional maturity by 20 days of the postnatal age in the rat.
在发育中的大鼠中，中脑边缘-纹状体中3,4-二羟基苯乙酸（DOPAC）的含量随年龄逐渐增加。腹腔注射阿扑吗啡（2毫克/千克）或氟哌啶醇（0.1毫克/千克）在第20天和第70天导致DOPAC含量发生显著变化，但在第7天没有。然而，更高剂量的阿扑吗啡（10毫克/千克，腹腔注射）或氟哌啶醇（5毫克/千克，腹腔注射）以及阿立哌唑（0.5毫克/千克，腹腔注射）显著影响7日龄大鼠中脑边缘-纹状体中DOPAC的含量。在24日龄大鼠中，用氟哌啶醇（1毫克/千克至10毫克/千克，皮下注射10天）进行亚慢性处理后，在撤药阶段，阿扑吗啡（2毫克/千克，腹腔注射）使中脑边缘中DOPAC的含量显著降低，但对照大鼠未出现这种情况。提示7日龄时对多巴胺激动剂和拮抗剂不充分敏感的中脑边缘-纹状体多巴胺（DA）受体在大鼠出生后20天达到功能成熟。
