Carpentier Y A, Druart M L, Delespesse G
Acta Chir Belg. 1981 Mar-Jun;80(2-3):149-55.
Twenty-one protein-calorie depleted patients were given for one week total parenteral nutrition (TPN) including Intralipid during a sixteen months' period (September 1975 - December 1976). Before TPN, lymphocyte proliferation response to 1 microgram/ml of phytohemagglutinin (PHA) was abnormally low, while immunoglobulin levels were in the normal range. After one week of TPN, lymphocyte response to PHA was significantly improved in patients exhibiting positive nitrogen balance but remained unchanged in the others. Immunoglobulin IgA, IGG, IgM levels tended to rise in most of the patients, while IgE concentrations remained unchanged. Addition of Intralipid at various concentrations to lymphocyte cultures of both patients and normal volunteers did not effect 3H-thymidine incorporation in the lymphocytes. Similarly, in vivo infusion of Intralipid in normal subjects did not have any effect on lymphocyte performance. This study shows that: 1. effective TPN can correct some alterations in immune parameters; 2. Intralipid does not seem to have any effect on the parameters measured in the present work.
在16个月期间（1975年9月至1976年12月），对21例蛋白质 - 热量消耗的患者进行了为期一周的全胃肠外营养（TPN），其中包括输注英脱利匹特。在进行TPN之前，患者对1微克/毫升植物血凝素（PHA）的淋巴细胞增殖反应异常低，而免疫球蛋白水平在正常范围内。经过一周的TPN治疗后，氮平衡呈阳性的患者对PHA的淋巴细胞反应显著改善，而其他患者则无变化。大多数患者的免疫球蛋白IgA、IgG、IgM水平趋于升高，而IgE浓度保持不变。向患者和正常志愿者的淋巴细胞培养物中添加不同浓度的英脱利匹特，对淋巴细胞中3H - 胸腺嘧啶核苷的掺入没有影响。同样，在正常受试者体内输注英脱利匹特对淋巴细胞功能也没有任何影响。本研究表明：1. 有效的TPN可以纠正免疫参数的一些改变；2. 英脱利匹特似乎对本研究中所测量的参数没有任何影响。
