Dionigi R, Dominioni L, Gnes F, Ballabio A
Ann Surg. 1977 Apr;185(4):467-74. doi: 10.1097/00000658-197704000-00017.
An experimental study was performed in 16 dogs to investigate the effects of sub-acute malnutrition on humoral and cellular immunity and phagocytic functions and, subsequently, to investigate the ability of total parenteral nutrition (TPN) to restore abnormal immunological variables. Deficiencies of IgG, C3, primary immune response to sheep red blood cells (SRBC),lymphocyte counts, lymphocyte response to phytohemagglutinin (PHA), and neutrophi chemotaxis were found to be caused by malnutrition. Nutritional repletion by means of TPN resulted in a return to normal or supranormal serum concentrations of IgG, IgM, and C3, and the primary immune response to SRVC was prompter and higher. Moreover, TPN resulted in restoration of normal neutrophil chemotactic responses. TPN did not improve lymphocyte response to PHA in these experiments. The study demonstrates that subacute malnutrition results in broad based deficiencies of the immunological response of the type that predispose to infection and that the proper use of TPN can correct most of these abnormalities.
对16只狗进行了一项实验研究，以调查亚急性营养不良对体液免疫、细胞免疫和吞噬功能的影响，随后研究全胃肠外营养（TPN）恢复异常免疫变量的能力。发现营养不良会导致IgG、C3缺乏，对绵羊红细胞（SRBC）的初次免疫反应、淋巴细胞计数、淋巴细胞对植物血凝素（PHA）的反应以及中性粒细胞趋化性降低。通过TPN进行营养补充导致IgG、IgM和C3的血清浓度恢复到正常或超正常水平，并且对SRBC的初次免疫反应更快、更强。此外，TPN导致中性粒细胞趋化反应恢复正常。在这些实验中，TPN并未改善淋巴细胞对PHA的反应。该研究表明，亚急性营养不良会导致广泛的免疫反应缺陷，这种缺陷易引发感染，并且正确使用TPN可以纠正这些异常中的大多数。
