Charbonnel B, Chupin M, Le Grand A, Guillon J
Acta Endocrinol (Copenh). 1981 Oct;98(2):178-83. doi: 10.1530/acta.0.0980178.
Thirty-six male patients with idiopathic haemochromatosis were subjected to measurements of basal plasma values of testosterone, LH and FSH and to an LRH test. Nineteen were also subjected to basal plasma determinations of T3, T4, cortisol, TSH and prolactin and to a TRH test. In 11 cases GH values were measured before, during and after an arginine infusion. Seventeen patients were found to hae low levels of testosterone, LH and FSH, and no gonadotrophin responses to LRH. Seventeen others had normal levels of these three hormones, with normal responses to LRH. The two remaining patients had normal testosterone values but very increased gonadotrophin values: a fact which remains unexplained. Basal levels of prolactin, GH, T3, T4, and TSH were normal: cortisol levels were either normal or increased in cases of poorly controlled diabetes. Prolactin responses to TRH were always normal. TSH responses to TRH were impaired in 2 cases, and GH responses to arginine in 3 cases. Considering that other factors may be involved in the few impairments found in TSH and GH stimulations, it is concluded that the only indisputable pituitary insufficiency in about half of the cases of idiopathic haemochromatosis is gonadotrophic.
36例特发性血色素沉着症男性患者接受了睾酮、促黄体生成素（LH）和促卵泡生成素（FSH）的基础血浆值测定以及促黄体生成素释放激素（LRH）试验。其中19例还接受了三碘甲状腺原氨酸（T3）、甲状腺素（T4）、皮质醇、促甲状腺激素（TSH）和催乳素的基础血浆测定以及促甲状腺激素释放激素（TRH）试验。11例患者在精氨酸输注前、期间和之后测量了生长激素（GH）值。发现17例患者睾酮、LH和FSH水平较低，对LRH无促性腺激素反应。另外17例这三种激素水平正常，对LRH反应正常。其余2例患者睾酮值正常，但促性腺激素值非常高：这一事实仍无法解释。催乳素、GH、T3、T4和TSH的基础水平正常：糖尿病控制不佳的患者皮质醇水平正常或升高。催乳素对TRH的反应始终正常。2例患者TSH对TRH的反应受损，3例患者GH对精氨酸的反应受损。考虑到TSH和GH刺激中发现的少数损害可能涉及其他因素，得出的结论是，在约一半的特发性血色素沉着症病例中，唯一无可争议的垂体功能不全是促性腺激素性的。
