Kinsella J E, Bruckner G, Mai J, Shimp J
Am J Clin Nutr. 1981 Oct;34(10):2307-18. doi: 10.1093/ajcn/34.10.2307.
Information concerning the metabolism of trans isomers of dietary unsaturated fatty acids is presented. Dietary trans-octadecenoic and trans,trans-octadecadienoic acids are apparently absorbed, activated, oxidized, and acylated into ester lipids much like saturated fatty acids although differences have been observed with regard to their metabolism by different organs. Because of the important role of linoleic acid as the principal precursor of cyclic endoperoxides, prostaglandins and leukotrienes, the potential deleterious effects of trans isomers of this acid are discussed. High levels of dietary trans,trans lineoleate can impair delta 6 desaturase activity and decrease prostaglandin production in rats on experimental diets.
本文介绍了膳食中不饱和脂肪酸反式异构体的代谢信息。膳食中的反式十八碳烯酸和反式，反式-十八碳二烯酸显然会被吸收、活化、氧化，并酰化形成酯脂，这与饱和脂肪酸的情况非常相似，尽管不同器官对它们的代谢存在差异。由于亚油酸作为环内过氧化物、前列腺素和白三烯的主要前体具有重要作用，因此讨论了该酸反式异构体的潜在有害影响。高含量的膳食反式，反式-亚油酸酯会损害实验饮食喂养的大鼠的δ6去饱和酶活性，并降低前列腺素的产生。
