慢性锂盐治疗后震颤的生理特征

Physiological characteristics of tremor after chronic lithium therapy.

作者信息

Tyrer P, Lee I, Trotter C

出版信息

Br J Psychiatry. 1981 Jul;139:59-61. doi: 10.1192/bjp.139.1.59.

DOI:10.1192/bjp.139.1.59

Abstract

Twenty-three patients taking lithium carbonate alone in therapeutic dosage for a mean period of 43 months (range 6--108 months) and 23 control subjects matched for age and sex had the frequency and amplitude of postural tremor measured and extrapyramidal symptoms assessed by standard techniques. Patients on lithium had a significantly lower peak frequency of tremor than control subjects (P less than 0.05) and significantly greater extrapyramidal symptoms (P less than 0.01), indicating that tremor appearing after chronic lithium therapy is likely to be an extrapyramidal symptom. Such symptoms are common long-term adverse effects of lithium carbonate.

摘要

23名单独服用治疗剂量碳酸锂平均43个月（范围6 - 108个月）的患者以及23名年龄和性别相匹配的对照受试者，测量了姿势性震颤的频率和幅度，并通过标准技术评估了锥体外系症状。服用锂盐的患者震颤的峰值频率显著低于对照受试者（P < 0.05），且锥体外系症状显著更严重（P < 0.01），这表明慢性锂盐治疗后出现的震颤可能是一种锥体外系症状。此类症状是碳酸锂常见的长期不良反应。