锂诱导阿尔茨海默病患者锥体外系症状加重
Lithium-induced accentuation of extrapyramidal symptoms in individuals with Alzheimer's disease.
作者信息
Kelwala S, Pomara N, Stanley M, Sitaram N, Gershon S
出版信息
J Clin Psychiatry. 1984 Aug;45(8):342-4.
PMID:6430878
Abstract
Lithium treatment in 9 elderly individuals with Alzheimer's disease led to a marked accentuation of extra-pyramidal symptoms (EPS) in 5 of 6 patients with preexisting EPS. EPS scores significantly correlated with plasma and RBC lithium levels. Lithium treatment had no such effects in the 3 patients without preexisting extrapyramidal symptoms.
摘要
对9名老年阿尔茨海默病患者进行锂治疗后，6名已有锥体外系症状（EPS）的患者中有5名出现明显的锥体外系症状加重。EPS评分与血浆和红细胞锂水平显著相关。锂治疗对3名无既往锥体外系症状的患者没有此类影响。
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