Long R G, Varghese Z, Skinner R K, Wills M R, Sherlock S
Clin Chim Acta. 1978 Aug 1;87(3):353-8. doi: 10.1016/0009-8981(78)90178-x.
Phosphate metabolism was investigated in 26 patients with a spectrum of liver diseases and mean fasting plasma phosphate concentrations were in the low normal range. A standard oral load of phosphate was used to test absorption and was subnormal in the majority of patients with large bile-duct obstruction and alcoholic liver disease. Subnormal results were also seen in patients with primary biliary cirrhosis and cirrhosis secondary to chronic active hepatitis. These abnormalities appeared to be related to vitamin-D deficiency. Tubular reabsorption of phosohate was markedly reduced in 3 of 14 patients. The therapeutic implications of phosphate status in liver disease are important.
对26例患有一系列肝脏疾病的患者的磷酸盐代谢进行了研究，其空腹血浆磷酸盐平均浓度处于正常低限范围。采用标准口服磷酸盐负荷试验来检测吸收情况，结果显示，大多数患有大胆管梗阻和酒精性肝病的患者吸收情况低于正常水平。原发性胆汁性肝硬化和慢性活动性肝炎继发的肝硬化患者也出现了低于正常水平的结果。这些异常情况似乎与维生素D缺乏有关。14例患者中有3例磷酸盐的肾小管重吸收明显减少。肝脏疾病中磷酸盐状态的治疗意义重大。
