口服1,25-二羟胆钙化醇对原发性胆汁性肝硬化钙和磷吸收不良的影响。
Effect of oral 1,25 dihydroxycholecalciferol on calcium and phosphate malabsorption in primary biliary cirrhosis.
作者信息
Farrington K, Epstein O, Varghese Z, Newman S P, Moorhead J F, Sherlock S
出版信息
Gut. 1979 Jul;20(7):616-9. doi: 10.1136/gut.20.7.616.
Abstract
Changes in calcium and phosphate absorption in response to treatment with small doses of oral 1,25 (OH)2D3 were studied in 10 patients with primary biliary cirrhosis by means of a combined radio-isotope technique. There was a marked improvement in the fractional rates of absorption of calcium (P less than 0.01) and phosphate (0.05 P less than 0.1) after treatment. This implies than there is no end organ unresponsiveness to the action of active Vitamin D metabolites at the intestinal level in primary biliary cirrhosis.
摘要
采用联合放射性同位素技术，对10例原发性胆汁性肝硬化患者口服小剂量1,25（OH）₂D₃治疗后钙和磷吸收的变化进行了研究。治疗后钙的吸收分数率（P＜0.01）和磷的吸收分数率（0.05＜P＜0.1）有显著改善。这意味着在原发性胆汁性肝硬化中，肠道水平的终末器官对活性维生素D代谢产物的作用不存在无反应性。
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