尿素用于抗利尿激素分泌异常综合征的长期治疗。
Urea for long-term treatment of syndrome of inappropriate secretion of antidiuretic hormone.
作者信息
Decaux G, Genette F
出版信息
Br Med J (Clin Res Ed). 1981 Oct 24;283(6299):1081-3. doi: 10.1136/bmj.283.6299.1081.
Abstract
The efficacy of oral urea in producing a sufficiently high osmotic diuresis was tested in seven patients with the syndrome of inappropriate secretion of antidiuretic hormone. In all patients urea corrected the hyponatraemia despite a normal fluid intake. Five patients were controlled (serum sodium concentration greater than 128 mmol(mEq)/1) with a dose of 30 g urea daily, and two with 60 g daily. The patients who needed 30 g drank 1-2 1 of fluid daily, while those who needed 60 g drank up to 3.1 per day. No major side effects were noted, even after treatment periods of up to 270 days. These findings suggest that urea is a safe and efficacious treatment of the syndrome of inappropriate secretion of antidiuretic hormone.
摘要
对7例抗利尿激素分泌不当综合征患者测试了口服尿素产生足够高渗透性利尿作用的效果。尽管液体摄入量正常，但在所有患者中尿素均纠正了低钠血症。5例患者每日服用30 g尿素得到控制（血清钠浓度大于128 mmol（mEq）/L），2例患者每日服用60 g尿素得到控制。需要30 g尿素的患者每日饮水1-2 L，而需要60 g尿素的患者每日饮水达3.1 L。即使在长达270天的治疗期后，也未观察到重大副作用。这些发现表明尿素是治疗抗利尿激素分泌不当综合征的一种安全有效的方法。
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