Watanabe F, Nakahara M, Tsubota N, Tsukida K, Saiki K, Ito M
Clin Chim Acta. 1978 Aug 15;88(1):21-5. doi: 10.1016/0009-8981(78)90143-2.
Investigation of the mechanism of the lowering effect of hydrochlorothiazide, which was administered orally, in the determination of estriol from the pregnancy urine has been carried out. The isolation and determination of the structure of a copolymer formed from estriol and formaldehyde have suggested the mechanism by which, during the acid hydrolysis process of the glucuronide conjugate of estriol, some copolymers of estriol and formaldehyde generated from hydrochlorothiazide, were formed, thus lowering the observed values of the estriol contents in the urine.
已对口服氢氯噻嗪在从妊娠尿中测定雌三醇时产生降低作用的机制进行了研究。对由雌三醇和甲醛形成的共聚物的结构进行分离和测定，提示了在雌三醇葡萄糖醛酸结合物的酸水解过程中，由氢氯噻嗪产生的一些雌三醇与甲醛的共聚物形成，从而降低了尿中雌三醇含量的观测值的机制。
