戈谢病和白血病性网状内皮增生症中抗酒石酸酸性磷酸酶的比较。
Comparison of the tartrate-resistant acid phosphatase in Gaucher's disease and leukemic reticuloendotheliosis.
作者信息
Lam K W, Li C Y, Yam L T, Desnick R J
出版信息
Clin Biochem. 1981 Aug;14(4):177-81. doi: 10.1016/s0009-9120(81)91201-7.
Tartrate-resistant acid phosphatase was isolated from serum and spleen of patients affected by Gaucher's disease. Electrophoretic and antigenic properties were compared to the enzyme isolated from hairy cells described in a previous study (9). The enzyme isolated from Gaucher serum has electrophoretic and antigenic properties identical to the acid phosphatase band 5b of hairy cells. The major tartrate-resistant acid phosphatase in the Gaucher spleen is band 5a. Bands 5a and 5b have identical protein structure indicated by their identical antigenicity. The removal of carbohydrate from band 5a by sialidase converted band 5a to 5b.
从戈谢病患者的血清和脾脏中分离出抗酒石酸酸性磷酸酶。将其电泳和抗原特性与先前研究（9）中从毛细胞分离出的酶进行比较。从戈谢病血清中分离出的酶具有与毛细胞酸性磷酸酶条带5b相同的电泳和抗原特性。戈谢病脾脏中的主要抗酒石酸酸性磷酸酶是条带5a。条带5a和5b具有相同的蛋白质结构，这由它们相同的抗原性表明。用唾液酸酶去除条带5a中的碳水化合物后，条带5a转变为5b。
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