Cohen B L, Katz M
Contraception. 1981 Aug;24(2):159-72. doi: 10.1016/0010-7824(81)90089-5.
Pituitary and ovarian function was evaluated in women receiving 3 combined oral contraceptive preparations. Basal levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) and gonadotropic responses to gonadotropic releasing hormone (GnRH) were studied in 36 healthy, regularly ovulating women in the early follicular and mid-luteal phases of their menstrual cycle (non-treatment, control). These same women were then divided into 3 groups with 12 volunteers in each. Each group received an oral contraceptive preparation cyclically for 3 months. The preparations were: Nordette (30 microgram ethinyl estradiol and 150 microgram d-norgestrel), Nordiol (50 microgram ethinyl estradiol and 250 microgram d-norgestrel) and Biphasil (50 microgram ethinyl estradiol and 50 microgram d-norgestrel X 11 days and 125 microgram d-norgestrel X 10 days). In the third month of treatment, the tests were repeated on day 21, i.e. after 21 active pills, and on day 28, i.e. after 21 active and 7 inactive tablets. On active therapy, basal FSH and LH were similarly suppressed in the 3 groups. LH had varied responses to a bolus of GnRH, whilst the FSH responses were similar in the 3 groups. After 7 days of inactive tablets, basal FSH and LH had returned to pre-treatment, early follicular phase levels. However, the LH responses to a bolus of GnRH varied in the 3 groups, but again, no differences were noted in the FSH responses. Basal FSH, LH and E2 recovered earlier in the Nordette group during the 7 days of inactive tablets.
对服用3种复方口服避孕药制剂的女性的垂体和卵巢功能进行了评估。在36名健康、月经周期规律且有排卵的女性月经周期的卵泡早期和黄体中期（未治疗，对照），研究了促卵泡生成素（FSH）和促黄体生成素（LH）的基础水平以及对促性腺激素释放激素（GnRH）的促性腺激素反应。然后将这些女性分为3组，每组12名志愿者。每组周期性服用一种口服避孕药制剂，为期3个月。这些制剂分别是：诺德婷（炔雌醇30微克和左炔诺孕酮150微克）、诺迪欧（炔雌醇50微克和左炔诺孕酮250微克）和双相炔诺孕酮片（炔雌醇50微克和左炔诺孕酮50微克，服用11天，然后左炔诺孕酮125微克，服用10天）。在治疗的第三个月，在第21天（即服用21片活性药片后）和第28天（即服用21片活性药片和7片无活性药片后）重复进行测试。在进行活性治疗时，3组中的基础FSH和LH均受到类似抑制。LH对GnRH推注有不同反应，而3组中的FSH反应相似。在服用7天无活性药片后，基础FSH和LH恢复到治疗前卵泡早期水平。然而，3组中LH对GnRH推注的反应各不相同，但FSH反应再次未发现差异。在服用7天无活性药片期间，诺德婷组的基础FSH、LH和雌二醇（E2）恢复得更早。
