有机染料与肝微粒体药物代谢单加氧酶的体外相互作用。
Interaction of organic dyes with hepatic microsomal drug-metabolizing monoöxygenases in vitro.
作者信息
Beyhl F E
出版信息
Experientia. 1981;37(9):943-5. doi: 10.1007/BF01971767.
PMID:6795054
Abstract
Organic dyes such as malachite green, methylene blue, fuchsin, safranine T, neutral red, phenazine methosulphate, riboflavin, dichlorophenolindophenol, phenolphthalein, and fluorescein, inhibit hepatic microsomal mixed-function oxidases and, partly, enhance, partly, inhibit hepatic microsomal NADPH-dependent cytochrome c and neotetrazolium reductases, in contrast to other inhibitors of drug metabolism which do not affect cytochrome c reductase but only interact with cytochrome P-450.
摘要
诸如孔雀绿、亚甲蓝、品红、番红T、中性红、吩嗪硫酸甲酯、核黄素、二氯酚靛酚、酚酞和荧光素等有机染料，会抑制肝微粒体混合功能氧化酶，并且部分增强、部分抑制肝微粒体中依赖烟酰胺腺嘌呤二核苷酸磷酸（NADPH）的细胞色素c和新四氮唑还原酶，这与其他药物代谢抑制剂不同，其他抑制剂不影响细胞色素c还原酶，仅与细胞色素P - 450相互作用。
Zotero 插件