Beyhl F E, Mayer D G
Arch Toxicol. 1980 Feb;43(4):257-62. doi: 10.1007/BF00366181.
In acute oral studies, the effect of bromobenzene on hepatic microsomal enzymes was investigated. Neither glucuronyltransferases nor cytochrome c reductase showed significant changes. Most of the mixed-function oxidases studied were inhibited with the exception of ketamine-N-demethylase. The data indicate that bromobenzene or its epoxide acts on cytochrome P-450 but not on all cytochrome P-450 species, and does not affect the reductase and the glucuronyltransferases. Microsomal lipoperoxidation and microsomal H2O2 formation were increased.
在急性口服研究中，研究了溴苯对肝微粒体酶的影响。葡糖醛酸转移酶和细胞色素c还原酶均未显示出显著变化。除氯胺酮-N-脱甲基酶外，所研究的大多数混合功能氧化酶均受到抑制。数据表明，溴苯或其环氧化物作用于细胞色素P-450，但并非作用于所有细胞色素P-450种类，且不影响还原酶和葡糖醛酸转移酶。微粒体脂质过氧化和微粒体过氧化氢生成增加。
