[Reactivity of the H-2ba mutant against the products of the H-2Kb gene and its mutant alleles in the graft vs. host reaction and the linkage with the H-2 complex of the nonresponsiveness of B10.M mice against the H-2kbd antigen].

Five mutants for the H-2Kb gene within the mouse major histocompatibility complex were studied in the Simonsen spleen weight assay. It was shown that H-2Kba mutant was unable to react against only H-2Kbd recipients, while developed normal reaction against H-2Kbf, H-2Kbg2, H-2Kbh mutants. These results indicate the specific character of the nonresponsiveness. Mice of the B10.M (H-2f) strain do not complement the defect of reactivity in the H-2Kba mutant. Evidence from the study of G2 hybrids indicate that the gene for nonresponsiveness in B 10.M was linked with the H-2 complex.