Nikonenko B V, Pospelov L E
Biull Eksp Biol Med. 1981 Apr;91(4):479-80.
Experiments were carried out on C57BL/6 (B6) (H-2b) mice and their derived mutants on H-2Kb gene: H-2Kbm1, H-2Kbm3 and H-2Kbm4. It was shown that tolerance of H-2Kbm1 mutant to H-2kb antigen diminishes the strength of rejection of skin grafts of H-2Kbm3 mutant donor. The H-2Kbm3 mutant tolerant to H-2Kbm1 antigen also showed weak rejection of maternal B6 recipient to H-2Kbm4 skin grafts. The tolerance induction of B6 recipients to H-2Kbm3 mutant antigen had no influence on the rejection of H-2Kbm1 skin grafts. The results are discussed from the standpoint of heterogenous clones of the cytotoxic lymphocytes reacting against H-2K molecules in the course of graft rejection.
实验在C57BL/6（B6）（H-2b）小鼠及其H-2Kb基因的衍生突变体：H-2Kbm1、H-2Kbm3和H-2Kbm4上进行。结果表明，H-2Kbm1突变体对H-2kb抗原的耐受性降低了H-2Kbm3突变体供体皮肤移植的排斥强度。对H-2Kbm1抗原有耐受性的H-2Kbm3突变体也显示出母体B6受体对H-2Kbm4皮肤移植的弱排斥反应。B6受体对H-2Kbm3突变体抗原的耐受性诱导对H-2Kbm1皮肤移植的排斥没有影响。从移植排斥过程中针对H-2K分子的细胞毒性淋巴细胞的异源克隆的角度对结果进行了讨论。
