二氯甲烷和一氧化碳吸入：大鼠体内碳氧血红蛋白的增加及药物代谢酶
Dichloromethane and carbon monoxide inhalation: carboxyhemoglobin addition, and drug metabolizing enzymes in rat.
作者信息
Kurppa K, Kivistö H, Vainio H
出版信息
Int Arch Occup Environ Health. 1981;49(1):83-7. doi: 10.1007/BF00380812.
PMID:6795133
Abstract
Male Wistar rats were exposed for 3 h to 100 ppm Co, 1,000 ppm dichloromethane, or to their combination. Exposure to dichloromethane alone or in combination with CO double the ethoxycoumarin O-deethylase activity in the kidney microsomes but not in the liver. An additive effect on blood COHb concentration by simultaneous exposure to CO and dichloromethane was observed. The mechanism of the additive effect is discussed.
摘要
将雄性Wistar大鼠暴露于100 ppm的一氧化碳、1000 ppm的二氯甲烷或它们的混合物中3小时。单独暴露于二氯甲烷或与一氧化碳联合暴露，会使肾微粒体中的乙氧香豆素O-脱乙基酶活性加倍，但肝脏中的该活性未加倍。观察到同时暴露于一氧化碳和二氯甲烷时，对血液中碳氧血红蛋白浓度有相加作用。文中讨论了相加作用的机制。
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