二氯甲烷作为镰状细胞血红蛋白中的抗镰变剂。
Dichloromethane as an antisickling agent in sickle cell hemoglobin.
作者信息
Schoenborn B P
出版信息
Proc Natl Acad Sci U S A. 1976 Nov;73(11):4195-9. doi: 10.1073/pnas.73.11.4195.
Abstract
Microscopic studies of red cells from homozygous sickle cell patients show that dichloromethane does prevent sickle cell formation in vitro and does cause reversion of sickled cells to normal after exposure to dichloromethane. X-ray structural analysis of human deoxyhemoglobin crystals exposed to dichloromethane shows four unique binding sites. Arguments are presented to suggest that the binding site close to tryptophan 14alpha prevents the formation of helical polymers, i.e., prevent sickling.
摘要
对纯合子镰状细胞病患者红细胞的显微镜研究表明，二氯甲烷在体外确实能防止镰状细胞形成，并且在暴露于二氯甲烷后确实能使镰状细胞恢复正常。对暴露于二氯甲烷的人脱氧血红蛋白晶体进行的X射线结构分析显示有四个独特的结合位点。有观点认为，靠近14α色氨酸的结合位点可防止螺旋聚合物的形成，即防止镰变。
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本文引用的文献
1
A MOLECULAR MECHANISM OF SICKLED ERYTHROCYTE FORMATION.镰状红细胞形成的分子机制。
Nature. 1964 Apr 18;202:258-60. doi: 10.1038/202258a0.
2
Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin.人类血红蛋白中的基因突变：正常血红蛋白与镰状细胞血红蛋白的化学差异。
Nature. 1957 Aug 17;180(4581):326-8. doi: 10.1038/180326a0.
3
Structure and function of haemoglobin. 3. A three-dimensional fourier synthesis of human deoxyhaemoglobin at 5.5 Angstrom resolution.血红蛋白的结构与功能。3. 5.5埃分辨率下人类脱氧血红蛋白的三维傅里叶合成。
J Mol Biol. 1967 Aug 28;28(1):117-56. doi: 10.1016/s0022-2836(67)80082-2.
4
Binding of xenon to sperm whale myoglobin.氙与抹香鲸肌红蛋白的结合。
Nature. 1965 Jul 3;207(992):28-30. doi: 10.1038/207028a0.
5
Binding of xenon to horse haemoglobin.氙与马血红蛋白的结合。
Nature. 1965 Nov 20;208(5012):760-2. doi: 10.1038/208760a0.
6
The effect of beta 73 Asn on the interactions of sickling hemoglobins.
Biochim Biophys Acta. 1970 Nov 17;221(2):373-5. doi: 10.1016/0005-2795(70)90279-5.
7
Dichloromethane and myoglobin function.二氯甲烷与肌红蛋白的功能。
Mol Pharmacol. 1973 Nov;9(6):835-9.
8
The interactions of sickle hemoglobin.镰状血红蛋白的相互作用。
Biochimie. 1972;54(5):633-8. doi: 10.1016/s0300-9084(72)80154-8.
9
Intermolecular organization of deoxygenated sickle haemoglobin determined by x-ray diffraction.通过X射线衍射确定的脱氧镰状血红蛋白的分子间组织。
Nature. 1972 Sep 22;239(5369):217-9. doi: 10.1038/239217a0.
10
Stereochemistry of cooperative effects in hemoglobin.血红蛋白协同效应的立体化学
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