二氯甲烷作为镰状细胞血红蛋白中的抗镰变剂。
Dichloromethane as an antisickling agent in sickle cell hemoglobin.
作者信息
Schoenborn B P
出版信息
Proc Natl Acad Sci U S A. 1976 Nov;73(11):4195-9. doi: 10.1073/pnas.73.11.4195.
Abstract
Microscopic studies of red cells from homozygous sickle cell patients show that dichloromethane does prevent sickle cell formation in vitro and does cause reversion of sickled cells to normal after exposure to dichloromethane. X-ray structural analysis of human deoxyhemoglobin crystals exposed to dichloromethane shows four unique binding sites. Arguments are presented to suggest that the binding site close to tryptophan 14alpha prevents the formation of helical polymers, i.e., prevent sickling.
摘要
对纯合子镰状细胞病患者红细胞的显微镜研究表明，二氯甲烷在体外确实能防止镰状细胞形成，并且在暴露于二氯甲烷后确实能使镰状细胞恢复正常。对暴露于二氯甲烷的人脱氧血红蛋白晶体进行的X射线结构分析显示有四个独特的结合位点。有观点认为，靠近14α色氨酸的结合位点可防止螺旋聚合物的形成，即防止镰变。
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