Kamidono S, Hamami G, Fujii A, Ishigami J
Invest Urol. 1981 Nov;19(3):176-8.
In the intraarterial infusion of anticancer drugs, the majority of systemic side effects are caused by the systemic circulation of the infused drug. If the extraregional infusate could be removed by hemodialysis (HD) or direct hemoperfusion (DHP), side effects in the intraarterial infusion therapies could be mitigated and regional administration of anticancer drugs in large doses would than be possible. To substantiate this postulate, the authors carried out in vivo experiments using mongrel dogs, and obtained the results evidencing removal of extra regional anticancer drugs by HD and DHP. The maximum mitomycin C clearance of HD was 35.7 ml per min, whereas that of DHP was 119.7 ml per min. The results show the usefulness of concomitant use of HD or DHP in the intraarterial infusion of anticancer drugs via internal iliac artery in the treatment of cancer of the urinary bladder.
在动脉内输注抗癌药物时，大多数全身副作用是由输注药物的全身循环引起的。如果能够通过血液透析（HD）或直接血液灌流（DHP）清除区域外的输注液，那么动脉内输注疗法的副作用就可以减轻，并且大剂量抗癌药物的区域给药将成为可能。为了证实这一假设，作者使用杂种狗进行了体内实验，并获得了通过HD和DHP清除区域外抗癌药物的结果。HD对丝裂霉素C的最大清除率为每分钟35.7毫升，而DHP为每分钟119.7毫升。结果表明，在通过髂内动脉进行动脉内输注抗癌药物治疗膀胱癌时，同时使用HD或DHP是有用的。
