Nakano Y
Hinyokika Kiyo. 1985 Jun;31(6):979-91.
Pharmacokinetics of anti-neoplastic agents (Cis-platinum: CDDP, Mitomycin C: MMC and Doxorubicin hydrochloride: ADM) in intra-arterial infusion chemotherapy with direct hemoperfusion (DHP) for bladder cancer were compared using dogs. For all of the three drugs, the blood drug concentration in peripheral veins of the group with DHP was lower than that of the group without DHP. The clearance of the DHP cartridges was relatively high, 82 ml/min for MMC, 76-79 ml/min for ADM, and 78 ml/min for CDDP at the end of the first 30 minutes. The clearance of MMC and ADM remained high throughout the following 90 minutes, but that of CDDP decreased with the increase in DHP operating time. The calculated amounts of the drugs adsorbed in the cartridges were 45.6 mg for CDDP, 19.2 mg for MMC and 42.0 mg for ADM, which were nearly half of the total administered doses. The urinary recovery rate of CDDP was 22.3% in the group with DHP and 41.8% in the group without DHP. The actual amount of CDDP adsorbed in the cartridges was 48.3% of the total administered dose, which makes the sum of urinary recovery rate and DHP adsorption rate 70%. The use of DHP was effective to eliminate the renal toxicity of the drug. This study shows that it is most effective when the use of DHP is completely simultaneous with intra-arterial infusion chemotherapy from the start to the end.
使用犬类比较了顺铂（CDDP）、丝裂霉素C（MMC）和盐酸阿霉素（ADM）这三种抗肿瘤药物在膀胱癌直接血液灌流（DHP）动脉内灌注化疗中的药代动力学。对于所有这三种药物，DHP组外周静脉血药浓度均低于无DHP组。DHP柱的清除率相对较高，在前30分钟结束时，MMC为82 ml/min，ADM为76 - 79 ml/min，CDDP为78 ml/min。在接下来的90分钟内，MMC和ADM的清除率一直保持较高水平，但CDDP的清除率随DHP操作时间的增加而降低。柱中吸附的药物计算量分别为：CDDP 45.6 mg、MMC 19.2 mg、ADM 42.0 mg，几乎是总给药剂量的一半。DHP组CDDP的尿回收率为22.3%，无DHP组为41.8%。柱中实际吸附的CDDP量占总给药剂量的48.3%，这使得尿回收率与DHP吸附率之和为70%。使用DHP可有效消除药物的肾毒性。本研究表明，从开始到结束，DHP与动脉内灌注化疗完全同时使用时最为有效。
