亚砜还原酶系统的进一步研究。

Further studies of sulfoxide-reducing enzyme system.

作者信息

Kitamura S, Tatsumi K, Hirata Y, Yoshimura H

出版信息

J Pharmacobiodyn. 1981 Jul;4(7):528-33. doi: 10.1248/bpb1978.4.528.

DOI:10.1248/bpb1978.4.528

Abstract

Various kinds of flavoenzymes such as NADPH-cytochrome c reductase, NADH-cytochrome b5 reductase, xanthine oxidase, lipoamide dehydrogenase and NADH dehydrogenase supplemented with their electron donors exhibited the sulfoxide reductase activity in the presence of a partially purified soluble factor from guinea pig liver. The present study suggests that new electron transfer systems in which the soluble factor functions as an electron carrier coupled with flavoenzymes described above are responsible for the sulfoxide reduction.

摘要

各种黄素酶，如NADPH - 细胞色素c还原酶、NADH - 细胞色素b5还原酶、黄嘌呤氧化酶、硫辛酰胺脱氢酶和NADH脱氢酶，在补充其电子供体的情况下，在存在豚鼠肝脏部分纯化的可溶性因子时表现出亚砜还原酶活性。本研究表明，可溶性因子作为电子载体与上述黄素酶偶联的新电子传递系统负责亚砜的还原。