Barnes R W, Brand R A, Clarke W, Hartley N, Hoak J C
Clin Orthop Relat Res. 1978 May(132):61-7.
A prospective randomized trial evaluated graded-compression antiembolism stockings for prevention of leg vein thrombosis as assessed by Doppler ultrasound, in patients undergoing total hip replacement. The study was terminated after the evaluation of 18 patients revealed a significantly greater incidence of deep vein thrombosis, documented by phlebography, in patients without stockings (5 of 10) compared to those with stockings (none of 8, p less than 0.03). Three of the patients with thrombosis developed pulmonary emboli. Although the sample size of this study is small, the implication that graded-compression stockings reduce the incidence of leg vein thrombosis is strong and is supported by the results of other recent trials. These findings are at variance with earlier studies which failed to document efficacy of elastic stockings, which involved products which did not provide graded limb compression.
一项前瞻性随机试验评估了分级加压抗栓袜对全髋关节置换患者预防腿部静脉血栓形成的效果,通过多普勒超声进行评估。在对18例患者进行评估后,该研究终止,静脉造影显示,未使用袜子的患者(10例中有5例)深静脉血栓形成的发生率显著高于使用袜子的患者(8例中无1例,p小于0.03)。3例血栓患者发生了肺栓塞。尽管该研究的样本量较小,但分级加压袜可降低腿部静脉血栓形成发生率这一结论证据充分,且得到了其他近期试验结果的支持。这些发现与早期研究不同,早期研究未能证明弹性袜的有效性,早期研究使用的产品未提供分级肢体加压。