Rickels K
Psychopharmacology (Berl). 1981;75(1):31-3. doi: 10.1007/BF00433497.
A reanalysis of 4-week data from a recently published study (Feighner et al. 1979) clearly demonstrate that in a significant subgroup of highly depressed patients who also suffer from at least moderate anxiety, significant treatment differences in favor of Limbitrol over AT were present not only after 1 or 2 weeks, but also after 4 weeks of treatment. These differences were not present in the less sick patients, a population in which AT was slightly favored. These findings suggest that not only is Limbitrol more effective than AT alone for a heterogeneous group of depressed patients with some concomitant anxiety during the early phases of treatment, but remains more effective that AT for a significant subgroup of highly depressed patients after 4 weeks of treatment.
对最近发表的一项研究（Feighner等人，1979年）的4周数据进行的重新分析清楚地表明，在一个同时患有至少中度焦虑症的高度抑郁症患者的重要亚组中，不仅在治疗1周或2周后，而且在治疗4周后，与去甲替林相比，多塞平/去甲替林片在治疗上存在显著差异，更有利于多塞平/去甲替林片。病情较轻的患者中不存在这些差异，在这部分患者中去甲替林稍有优势。这些发现表明，对于一组伴有一些焦虑症的异质性抑郁症患者，多塞平/去甲替林片在治疗早期不仅比单独使用去甲替林更有效，而且在治疗4周后，对于一个高度抑郁症患者的重要亚组，多塞平/去甲替林片仍然比去甲替林更有效。
