UK-37,248，一种新型的选择性血栓素合成酶抑制剂，具有血小板抗聚集和抗血栓形成活性。 - Suppr

Suppr

超能文献

UK-37, 248, a novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity.

作者信息

Randall M J, Parry M J, Hawkeswood E, Cross P E, Dickinson R P

出版信息

Thromb Res. 1981;23(1-2):145-62. doi: 10.1016/0049-3848(81)90247-4.

DOI:10.1016/0049-3848(81)90247-4

PMID:6795753

Abstract

摘要

相似文献

UK-37, 248, a novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity.UK-37,248，一种新型的选择性血栓素合成酶抑制剂，具有血小板抗聚集和抗血栓形成活性。

Thromb Res. 1981;23(1-2):145-62. doi: 10.1016/0049-3848(81)90247-4.

Effects of thromboxane synthetase inhibition on arachidonate metabolism and platelet behaviour.血栓素合成酶抑制对花生四烯酸代谢及血小板行为的影响。

Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):23S-29S. doi: 10.1111/j.1365-2125.1983.tb02103.x.

Inhibition of platelet aggregation by 1-alkylimidazole derivatives, thromboxane A synthetase inhibitors.1-烷基咪唑衍生物（血栓素A合成酶抑制剂）对血小板聚集的抑制作用

Prostaglandins. 1981 Apr;21(4):543-54. doi: 10.1016/0090-6980(81)90003-4.

Biochemical and pharmacological evaluation of thromboxane synthetase inhibitors.血栓素合成酶抑制剂的生化与药理学评价

Adv Prostaglandin Thromboxane Res. 1980;6:417-25.

A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid. Two selective thromboxane synthetase inhibitors.咪唑与9,11-偶氮前列-5,13-二烯酸的比较。两种选择性血栓素合成酶抑制剂。

Biochim Biophys Acta. 1978 Mar 1;539(2):162-72. doi: 10.1016/0304-4165(78)90003-x.

Thromboxane synthetase inhibition as antithrombotic strategy.抑制血栓素合成酶作为抗血栓形成策略。

Lancet. 1981 May 16;1(8229):1073-5. doi: 10.1016/s0140-6736(81)92241-8.

Effect of the thromboxane synthetase inhibitor UK-37,248 (dazoxiben) upon platelet aggregation, coronary artery thrombosis and vascular reactivity.血栓素合成酶抑制剂UK-37,248（达唑氧苯）对血小板聚集、冠状动脉血栓形成及血管反应性的影响。

J Pharmacol Exp Ther. 1983 Dec;227(3):790-6.

Inhibition of arachidonate-induced human platelet aggregation by a single low oral dose of aspirin in combination with a thromboxane synthase inhibitor.

Thromb Haemost. 1984 Oct 31;52(2):215.

Effects of Y-20811, a long-lasting thromboxane synthetase inhibitor, on thromboxane production and platelet function.长效血栓素合成酶抑制剂Y-20811对血栓素生成及血小板功能的影响。

Thromb Res. 1986 Aug 15;43(4):455-68. doi: 10.1016/0049-3848(86)90090-3.

Lag-phase of arachidonic acid-induced secretion in responders and non-responders to the thromboxane-synthetase inhibitors: involvement of cyclic-AMP.对血栓素合成酶抑制剂有反应者和无反应者中花生四烯酸诱导分泌的延迟期：环磷酸腺苷的作用。

Thromb Res. 1984 Jul 1;35(1):91-7. doi: 10.1016/0049-3848(84)90316-5.

引用本文的文献

The Concise Guide to PHARMACOLOGY 2013/14: enzymes.《2013/14药理学简明指南：酶类》

Br J Pharmacol. 2013 Dec;170(8):1797-867. doi: 10.1111/bph.12451.

Prostanoid receptor antagonists: development strategies and therapeutic applications.前列腺素受体拮抗剂：研发策略与治疗应用。

Br J Pharmacol. 2009 Sep;158(1):104-45. doi: 10.1111/j.1476-5381.2009.00317.x. Epub 2009 Jul 15.

Mechanisms of bradykinin-induced contraction of the guinea-pig gallbladder in vitro.豚鼠胆囊体外缓激肽诱导收缩的机制

Br J Pharmacol. 1995 Apr;114(8):1549-56. doi: 10.1111/j.1476-5381.1995.tb14938.x.

Salutary actions of thromboxane synthetase inhibition during global myocardial ischemia.在全心肌缺血期间血栓素合成酶抑制的有益作用。

Naunyn Schmiedebergs Arch Pharmacol. 1982 Nov;321(2):130-4. doi: 10.1007/BF00518480.

Thromboxane A2 mediates lung vasoconstriction but not permeability after endotoxin.血栓素A2介导内毒素后的肺血管收缩，但不介导通透性。

J Clin Invest. 1983 Sep;72(3):911-8. doi: 10.1172/JCI111062.

Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with dazoxiben hydrochloride (UK 37,248-01).兔急性动脉血栓形成：盐酸达唑昔本（UK 37,248 - 01）治疗后血小板聚集减少

Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):49S-55S. doi: 10.1111/j.1365-2125.1983.tb02107.x.

Dazoxiben examined for platelet inhibitory effect in an artificial circulation.对大唑昔本进行人工循环中的血小板抑制作用研究。

Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):61S-65S. doi: 10.1111/j.1365-2125.1983.tb02109.x.

Dazoxiben: a pharmacological tool or clinical candidate?达唑氧苯：一种药理学工具还是临床候选药物？

Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):13S-16S. doi: 10.1111/j.1365-2125.1983.tb02101.x.

Pathophysiological mechanisms of sudden death induced by platelet activating factor.血小板活化因子所致猝死的病理生理机制

Br J Pharmacol. 1984 Sep;83(1):125-30. doi: 10.1111/j.1476-5381.1984.tb10126.x.

Prostacyclin and thromboxanes in carrageenan-induced pleurisy in the rat.前列腺素和血栓素在角叉菜胶诱导的大鼠胸膜炎中的作用

Agents Actions. 1984 Jan;14(1):76-81. doi: 10.1007/BF01966837.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验