Punnonen R, Nyman D, Grönroos M, Wallén O
Acta Obstet Gynecol Scand. 1981;60(5):507-9. doi: 10.3109/00016348109155470.
Seven new cases of pregnancy combined with von Willebrand's disease have been reported. Altogether the patients had 11 deliveries, and one abortion after 10 weeks' gestation. The diagnosis was based on the determination of the bleeding time, factor VIII coagulant activity (VIII C), factor VIII-related antigen (VIII RAg) and the ristocetin cofactor (VIII RCoF). Two of our 6 parturients showed profuse bleeding at delivery; in addition one patient showed bleeding after abortion at 10 weeks' gestation. Vaginal delivery is generally safe in patients with von Willebrand's disease. There is a great risk of copious bleeding especially in connection with early abortion, when factor VIII levels are low.
已有7例妊娠合并血管性血友病的新病例报告。这些患者总共分娩11次，1例在妊娠10周后流产。诊断基于出血时间、凝血因子VIII促凝活性（VIII C）、凝血因子VIII相关抗原（VIII RAg）和瑞斯托霉素辅因子（VIII RCoF）的测定。我们的6名产妇中有2名在分娩时出现大量出血；此外，1名患者在妊娠10周流产后出血。血管性血友病患者阴道分娩一般是安全的。尤其是在早期流产且凝血因子VIII水平较低时，有大量出血的巨大风险。
