Synthesis and in vitro activity of aurodox carbamoyl-methyl ether and aurodox 2,4-dinitrophenylhydrazone.

The synthesis of aurodox carbamoyl-methyl ether and aurodox 2,4,-dinitrophenylhydrazone from aurodox sodium salt is described. Both synthetic analogs were found to have virtually the same ability of the original antibiotic to inhibit poly(U)-directed poly(phenylalanine) synthesis in the in vitro system of E. coli. This indicates that derivatization at the acid hydroxy and cheto functions does not affect the protein synthesis inhibitory activity of aurodox.