Price J L, Gibbs N M
Clin Radiol. 1978 Jul;29(4):447-52. doi: 10.1016/s0009-9260(78)80109-3.
The relationship of microcalcification to lobulo-ductal dysplasia and non-invasive carcinoma was studied in 20 women with in situ carcinoma of the breast. All had microcalcification on the mammogram and in half there was also mammographic evidence of disruption of the breast structure. Three-quarters of the women presented with breast symptoms. Multifocal carcinoma was found in seven patients and the histology suggested that not all foci may progess to extensive duct infiltration or invasion. Calcification was found to occur both in carcinoma and in adjacent benign breast lesions and in three cases no evidence of calcification was found in the carcinoma, but was present in adjacent epitheliosis. The origin and distribution of microcalcification appears to be the same in epithelial hyperplasia, non-invasive carcinoma and invasive carcinoma and there may be a relationship between the amount of calcification and the activity of the epithelial cells. Microcalcification is not specific to breast cancer, but is a product of increased cellular activity in the lobulo-ductal complex and may be extruded into the surrounding interstitial tissue. This implies that microcalcification on the mammogram, particularly if sparse, demonstrates a high risk area of breast rather than a certainty of the presence of carcinoma.
对20例乳腺原位癌女性患者的微钙化与小叶导管发育异常及非浸润性癌的关系进行了研究。所有患者乳房X线照片上均有微钙化，其中半数还有乳房结构破坏的乳房X线证据。四分之三的女性有乳房症状。7例患者发现多灶性癌，组织学检查表明并非所有病灶都会发展为广泛的导管浸润或浸润。发现钙化既存在于癌组织中，也存在于相邻的良性乳腺病变中，3例癌组织中未发现钙化证据，但相邻的上皮增生中有钙化。微钙化的起源和分布在上皮增生、非浸润性癌和浸润性癌中似乎相同，钙化量与上皮细胞活性之间可能存在关联。微钙化并非乳腺癌所特有，而是小叶导管复合体中细胞活性增加的产物，可能会被挤出到周围的间质组织中。这意味着乳房X线照片上的微钙化，尤其是稀疏的微钙化，显示的是乳腺的高风险区域，而非确定存在癌。
