Ohta T, Matsuda I
Clin Chim Acta. 1981 Dec 9;117(2):133-43. doi: 10.1016/0009-8981(81)90034-6.
Plasma lipids and 6 plasma apolipoproteins (apoA-I, apoA-II, apoB, apoC-I, apoC-II and apoC-III) were studied in 23 patients with nephrotic syndrome. The elevated total cholesterol, triglyceride and apoB levels in nephrotic patients decreased gradually, after the disappearance of proteinuria. During the acute stage high density lipoprotein cholesterol, as well as the sum of apoA-I and apoA-II were similar in the patients and the controls. ApoA-I and apoA-II were transiently elevated during the recovery stage. All three apoC proteins (apoC-I, apoC-II and apoC-III) were elevated during the acute stage. A significant decrease in apoC-I, apoC-II and apoC-III was observed during the first 3 weeks after normalization of the urine protein. The ratio of apoC-II/apoC-III was reduced during the first 4 weeks after normalization of urine protein and then returned to the control level. The results suggest that as far as total levels are concerned, changes of apoC-II, apoC-III and the ratio of apoC-II/apoC-III appear to have no effect on the development of hyperlipidemia in th nephrotic syndrome.
对23例肾病综合征患者的血浆脂质和6种血浆载脂蛋白（载脂蛋白A-I、载脂蛋白A-II、载脂蛋白B、载脂蛋白C-I、载脂蛋白C-II和载脂蛋白C-III）进行了研究。肾病患者总胆固醇、甘油三酯和载脂蛋白B水平升高，蛋白尿消失后逐渐下降。急性期患者的高密度脂蛋白胆固醇以及载脂蛋白A-I和载脂蛋白A-II的总和与对照组相似。载脂蛋白A-I和载脂蛋白A-II在恢复期短暂升高。急性期所有三种载脂蛋白C（载脂蛋白C-I、载脂蛋白C-II和载脂蛋白C-III）均升高。尿蛋白正常化后的前3周，载脂蛋白C-I、载脂蛋白C-II和载脂蛋白C-III显著下降。尿蛋白正常化后的前4周，载脂蛋白C-II/载脂蛋白C-III的比值降低，然后恢复到对照水平。结果表明，就总水平而言，载脂蛋白C-II、载脂蛋白C-III以及载脂蛋白C-II/载脂蛋白C-III的比值变化似乎对肾病综合征高脂血症的发生没有影响。
