大鼠和兔体内亲骨性放射性核素的死后迁移及其对骨摄取估计值的影响。

Post-mortem migration of bone-seeking radionuclides in the rat and rabbit and its effect on estimates of bone uptake.

Tothill P, Macpherson J N

Clin Sci Mol Med. 1978 Aug;55(2):221-3. doi: 10.1042/cs0550221.

Abstract

The continued uptake of 18F, 85Sr and 47Ca by bone after death has been studied in rats and rabbits after aortic injection followed by quick killing, a period of recirculation of tracer before death, and perfusion of the carcase. In each case an approximately linear increase of bone radioactivity was observed during a period of 1 h at about the same rate. The proportionate increase depended on the initial concentration of bone-seeking nuclide, ranging from a factor of 1.5 to 4.5. Boiling the carcase did not increase the migration rate. 2. Delay between death and dissection may therefore lead to spuriously high bone concentrations of these radionuclides, leading to over-estimates of bone uptake, extraction ratio or bone blood flow.

摘要

对大鼠和兔子在主动脉注射后快速处死、在死亡前有一段时间示踪剂再循环以及对尸体进行灌注的情况下，研究了死后骨骼对¹⁸F、⁸⁵Sr和⁴⁷Ca的持续摄取情况。在每种情况下，在约1小时的时间段内观察到骨骼放射性以大致相同的速率呈近似线性增加。成比例的增加取决于亲骨性核素的初始浓度，范围为1.5至4.5倍。煮沸尸体并未增加迁移速率。2. 因此，死亡与解剖之间的延迟可能导致这些放射性核素在骨骼中的浓度出现假性升高，从而导致对骨摄取、提取率或骨血流量的高估。