镧对犬皮质骨中47Ca和85Sr转运的抑制作用。
Inhibition of transport of 47Ca and 85Sr by lanthanum in canine cortical bone.
作者信息
Paradis G R, Bassingthwaighte J B, Kelly P J
出版信息
J Appl Physiol. 1974 Feb;36(2):221-5. doi: 10.1152/jappl.1974.36.2.221.
Deposition of Sr and Ca and blood flow (measured by iodoantipyrine washout) were determined in the tibial cortex of adult dogs after injection of graded doses of lanthanum chloride (LaCl) and potassium cyanide (KCN) into the right tibial nutrient artery. Deposition of Sr and Ca, expressed in milliliters per gram of cortical bone in 10 min, was decreased after injections of lanthanum, 0.045 ± 0.008 (mean ± SE) compared to 0.097 ± 0.01 in control experiments ( < 0.005). Blood flow was unchanged. Injection of KCN did not affect the mean value of uptake of mineral (0.108 ± 0.01 vs. 0.097 ± 0.01) over the whole range of KCN dosage. Blood flow tended to be slightly higher with lower doses of KCN. These data support the concept of a transport system in bone for bone-seeking isotopes such as Sr and Ca.
向成年犬右胫骨滋养动脉注射不同剂量的氯化镧（LaCl）和氰化钾（KCN）后，测定了其胫骨皮质中锶（Sr）和钙（Ca）的沉积以及血流量（通过碘安替比林洗脱法测量）。以每克皮质骨在10分钟内沉积的毫升数表示，注射镧后Sr和Ca的沉积量减少，为0.045±0.008（平均值±标准误），而对照实验中为0.097±0.01（P<0.005）。血流量未发生变化。在整个KCN剂量范围内，注射KCN并未影响矿物质摄取的平均值（0.108±0.01对比0.097±0.01）。较低剂量的KCN使血流量倾向于略高。这些数据支持了骨骼中存在针对诸如Sr和Ca等亲骨性同位素的转运系统这一概念。
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