Abrahamson S, Würgler F E, DeJongh C, Meyer H U
Environ Mutagen. 1980;2(4):447-53. doi: 10.1002/em.2860020403.
The sensitivity of the sex-linked recessive lethal test is due to the fact that a very large number of loci are included i the mutation study. From extensive studies on the spontaneous sex-linked recessive lethal frequency and spontaneous specific locus mutation rates, it is possible to derive an estimate of the number of loci included in the recessive lethal test. The average number derived from three estimates on male and female germ cells is 563 loci. A second independent approach derives from published data which analyzed short regions of he genome and the proportion of loci within these regions which mutate to lethality. This analysis suggests that 830 loci are potentially lethal mutables. We describe the reasons for concluding that 600 to 800 loci of the approximately 1,000 loci on the X-chromosome are involved in the X-linked recessive lethal test.
性连锁隐性致死试验的敏感性源于这样一个事实，即大量基因座被纳入突变研究中。通过对自发性性连锁隐性致死频率和自发性特定基因座突变率的广泛研究，可以得出隐性致死试验中所包含基因座数量的估计值。从对雄性和雌性生殖细胞的三项估计得出的平均基因座数量为563个。第二种独立方法来自已发表的数据，这些数据分析了基因组的短区域以及这些区域内突变为致死性的基因座比例。该分析表明，有830个基因座可能发生致死性突变。我们阐述了得出以下结论的原因：在X染色体上大约1000个基因座中，有600至800个基因座参与了X连锁隐性致死试验。
