通过果蝇的翅、眼和雌性生殖系镶嵌试验以及性连锁隐性致死试验确定了福美双的遗传毒性。

Genotoxicity of ziram established through wing, eye and female germ-line mosaic assays and the sex-linked recessive lethal test in Drosophila melanogaster.

作者信息

Tripathy N K, Majhi B, Dey L, Das C C

机构信息

Department of Zoology, Berhampur University, India.

出版信息

Mutat Res. 1989 Oct;224(2):161-9. doi: 10.1016/0165-1218(89)90152-3.

DOI:10.1016/0165-1218(89)90152-3

PMID:2507911

Abstract

The genotoxicity of ziram (zinc-dimethyl dithiocarbamate, CAS No. 137-30-4), a carbamate fungicide, is studied in the wing, eye and female germ-line mosaic assays and the sex-linked recessive lethal test in Drosophila melanogaster. First-, second- and third-instar larvae, carrying suitable recessive genetic markers on their first and third chromosomes, were exposed to ziram. Wings and eyes of adults were screened for the induction of mosaic spots and the eggs laid by adult females for germ-line mosaicism. The Basc method was used to detect sex-linked recessive lethals. Ziram is genotoxic to the somatic and germ cells of Drosophila melanogaster.

摘要

福美锌（二甲基二硫代氨基甲酸锌，化学物质登记号：137 - 30 - 4）是一种氨基甲酸酯类杀菌剂，其遗传毒性通过黑腹果蝇的翅、眼及雌性生殖系镶嵌试验和伴性隐性致死试验进行研究。携带位于其第一和第三条染色体上合适隐性遗传标记的一龄、二龄和三龄幼虫被暴露于福美锌。对成年果蝇的翅和眼进行筛选，以检测镶嵌斑的诱导情况，并对成年雌蝇所产的卵进行筛选，以检测生殖系镶嵌现象。采用Basc方法检测伴性隐性致死。福美锌对黑腹果蝇的体细胞和生殖细胞具有遗传毒性。