Tice A W, Rodriguez V L
JAMA. 1981 Dec 11;246(23):2717-9.
Cultures of genital sites and pharynx were obtained from 903 prostitutes and 102 active-duty men at Clark AFB, Republic of the Philippines, during the first quarter of 1981. Slightly more than 2.2% positive pharyngeal cultures in the women and 6% in the men were noted. Both penicillin-sensitive and penicillinase-producing Neisseria gonorrhoeae (PPNG) were recovered. Treatment and follow-up of the pharyngeal infections were available only for the men seen at the Clark Public Health Clinic. These men responded to penicillin G procaine for penicillin-sensitive N gonorrhoeae and to spectinomycin hydrochloride for PPNG. A retrospective review of cases of male gonococcal urethritis seen in 1980 in the Clark Public Health Clinic revealed 46 cases of probable oral-to-genital transfer of N gonorrhoeae among more than 2,600 cases of gonococcal urethritis. Of these 46, fifteen were PPNG. The importance of the pharynx as a source of infection is thus substantiated.
1981年第一季度,从菲律宾共和国克拉克空军基地的903名妓女和102名现役男性身上采集了生殖器部位和咽部的培养样本。结果发现,女性咽部培养样本阳性率略高于2.2%,男性为6%。培养样本中分离出了对青霉素敏感的淋病奈瑟菌和产青霉素酶淋病奈瑟菌(PPNG)。只有在克拉克公共卫生诊所就诊的男性接受了咽部感染的治疗及随访。这些男性对治疗青霉素敏感淋病奈瑟菌的普鲁卡因青霉素G以及治疗PPNG的盐酸大观霉素均有反应。对1980年在克拉克公共卫生诊所就诊的男性淋菌性尿道炎病例进行回顾性分析发现,在2600多例淋菌性尿道炎病例中,有46例可能存在淋病奈瑟菌的口-生殖器传播。在这46例中,有15例为PPNG。因此,咽部作为感染源的重要性得到了证实。