Effects of adjuvants on the immunogenicity of Habu-venom toxoid in the monkey and the guinea pig.

Incorporation of aluminum adjuvant as large an amount as 1 mg/ml (as Al) in immunization was required to produce high antibody titers against Habu-venom toxoid. The adjuvanticity of aluminum hydroxide was superior to that of aluminum phosphate. When used in combination with poly-L-lysine, a smaller amount of aluminum was needed to produce the same level of antibody titer as that produced with aluminum alone.