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S-Adenosylhomocysteine hydrolase activity in a lymphoblastoid cell line from a patient with adenosine deaminase dificiency disease.

作者信息

Tsuchiya S, Nakae S, Konno T, Tada K

出版信息

J Inherit Metab Dis. 1981;4(4):197-201. doi: 10.1007/BF02263651.

DOI:10.1007/BF02263651
PMID:6796770
Abstract

S-Adenosylhomocysteine (S-AdoHcy) hydrolase activity in a lymphoblastoid cell line from a patient with adenosine deaminase deficiency disease (ADA(-)LCL) was found to be approximately 60% of that in ADA (+)lymphoblastoid cell lines. S-AdoHcy hydrolase of ADA(-)LCL was more sensitive to inhibition by 2'-deoxyadenosine as compared with that of ADA(+)LCL. The inhibitory effect of 2'-deoxyadenosine was evident in cell growth and immunoglobulin production of lymphoblastoid cell lines.

摘要

相似文献

1
S-Adenosylhomocysteine hydrolase activity in a lymphoblastoid cell line from a patient with adenosine deaminase dificiency disease.
J Inherit Metab Dis. 1981;4(4):197-201. doi: 10.1007/BF02263651.
2
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本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Epstein-Barr virus-induced lymphoblastoid cell lines from patients with primary immunodeficiency diseases.来自原发性免疫缺陷疾病患者的爱泼斯坦-巴尔病毒诱导的淋巴母细胞系。
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3
Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity.两名细胞免疫严重受损患者的腺苷脱氨酶缺乏症。
Lancet. 1972 Nov 18;2(7786):1067-9. doi: 10.1016/s0140-6736(72)92345-8.
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S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity.
Science. 1978 Nov 17;202(4369):757-60. doi: 10.1126/science.715439.
5
Inhibition of methylation by adenosine in adenosine deaminase-inhibited, phytohemagglutinin-stimulated human lymphocytes.腺苷对腺苷脱氨酶抑制的、植物血凝素刺激的人淋巴细胞中甲基化的抑制作用。
J Immunol. 1979 Jul;123(1):97-103.
6
Selective toxicity of purine deoxynucleosides for human lymphocyte growth and function.嘌呤脱氧核苷对人淋巴细胞生长和功能的选择性毒性。
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1998-2002. doi: 10.1073/pnas.76.4.1998.
7
The effect of nucleosides and deoxycoformycin on adenosine and deoxyadenosine inhibition of human lymphocyte activation.核苷和脱氧助间型霉素对腺苷及脱氧腺苷抑制人淋巴细胞活化的影响。
J Immunol. 1979 Jul;123(1):189-93.
8
In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients.腺苷脱氨酶缺乏患者中2'-脱氧腺苷对红细胞S-腺苷同型半胱氨酸水解酶的体内失活作用
J Clin Invest. 1979 Apr;63(4):807-11. doi: 10.1172/JCI109367.
9
Differential inhibition of adenosine deaminase deficient peripheral blood lymphocytes and lymphoid line cells by deoxyadenosine and adenosine.
Cell Immunol. 1979 Feb;42(2):418-23. doi: 10.1016/0008-8749(79)90207-7.
10
Apparent suicide inactivation of human lymphoblast S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine and adenine arabinoside. A basis for direct toxic effects of analogs of adenosine.2'-脱氧腺苷和阿糖腺苷对人淋巴母细胞S-腺苷同型半胱氨酸水解酶的明显自杀性失活作用。腺苷类似物直接毒性作用的一个基础。
J Biol Chem. 1979 Jan 10;254(1):22-5.