Pappas B A, Vogel R A, Wilson J H, Mueller R A, Breese G R
Pharmacol Biochem Behav. 1981 Nov;15(5):743-6. doi: 10.1016/0091-3057(81)90016-2.
In the present study, the effect of various stimulant drugs on the action of chlordiazepoxide to increase punished responding was studied. Drugs such as d-amphetamine, methylphenidate and imipramine that are effective in attentional deficit disorder (MBD) were found to reverse this benzodiazepine-induced increase in responding. Phenobarbital which worsens this condition enhanced the benzodiazepine effect. Since the impairment caused by chlordiazepoxide may be analogous to the lack of impulse control noted in MBD, the bupropion antagonism of this action of chlordiazepoxide suggests that bupropion may be useful in MBD.
在本研究中，研究了各种兴奋剂药物对氯氮卓增加受罚反应作用的影响。发现对注意力缺陷障碍（MBD）有效的药物，如右旋苯丙胺、哌醋甲酯和丙咪嗪，可逆转这种苯二氮卓类药物引起的反应增加。使这种情况恶化的苯巴比妥增强了苯二氮卓类药物的作用。由于氯氮卓引起的损害可能类似于MBD中所指出的缺乏冲动控制，安非他酮对氯氮卓这一作用的拮抗作用表明安非他酮可能对MBD有用。
