BCG vaccine responses following simultaneous immunization against influenza and tuberculosis. 2nd report.

Following observations over 200 guinea-pigs, 48 rabbits and 105 volunteers practical data have been obtained as to an identical vaccination efficacy of BCG applied simultaneously with influenza vaccine also. The identity of local reactions to the administration of BCG and an identical post-vaccination tuberculin sensitivity have been proved. BCG immunogenicity when applied separately and simultaneously with influenza vaccines has been traced. Out of those inactivated vaccine and BCG exerted upon one another an effect intensifying antibody production. The evaluation of tuberculosis antibodies (antipolysaccharides, antiphosphatides and antiproteins) has been carried out with two serologic tests (I.H.T. and C.F.T.). After challenging animals with influenza virus and M. tuberculosis a fall of the heterogen antibody level and a stimulation of the specific antibody accumulation could be seen. The survival time, weight and correlation between antibody formation and the results of challenge have also been traced. In the observations over volunteers the absence of a negative effect of influenza vaccines following their simultaneous application with BCG has been proved. The periods and the character of the cutaneous reaction to the vaccine injection remain changed. Tuberculin sensitivity develops in an identical way.