Influenza vaccine response following its simultaneous application with BCG 1st report.

Different regimens for vaccination against influenza and tuberculosis were compared on the basis of experiments with Guinea-pigs and rabbits and observations of human volunteers. Influenza vaccines (live and inactivated) and BCG were given separately and simultaneously. No unfavourable influence of these vaccines upon one another was observed. Clinic and laboratory indices of vaccine efficacy under both conditions were identical. BCG did not influence the postvaccination virus shedding of a live influenza vaccine. The immunogenicity of influenza vaccines given simultaneously with BCG appeared to be improved. The evaluation of live and inactivated influenza vaccines under different schemes show that the inactivated influenza vaccine (AGH) has greater immunogenicity. The distinction was also evident in evaluations of vaccine efficacy in animals after challenge with pathogenic influenza virus. These findings indicate that the simultaneous application of influenza and tuberculosis vaccines should be further investigated.