Misiuk N S, Kurgaev V I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1981;81(8):1149-52.
On giving a dose of glycerol (orally), mannitol or lasix (intravenously) to patients with a cerebral stroke in the acute period the cerebrospinal fluid (CSF) pressure in them dropped, on the average, by 70-80%, 65-70%, and 25-30%, respectively. However in 6.5 to 7.5 hours it rose again and the after-effect phenomenon appeared. The effects of the drugs having been over, the CSF pressure was found to exceed the initial level by 50-60% after the glycerol intake; by 75 to 80% after the mannitol, an by 4 to 6% after the lasix injections. When glycerol, mannitol, and lasix were given rectally the CSF pressure dropped, respectively, by 35-45%, 35-40%, and 20-25% below the initial level, and did not rise throughout the whole period of the observation.
在急性期给脑卒中患者口服一剂甘油、静脉注射甘露醇或速尿后，他们的脑脊液（CSF）压力平均分别下降了70 - 80%、65 - 70%和25 - 30%。然而，在6.5至7.5小时后，脑脊液压力又再次升高，并出现了后效应现象。药物作用消失后，发现口服甘油后脑脊液压力超过初始水平50 - 60%；静脉注射甘露醇后超过75 - 80%；注射速尿后超过4 - 6%。当经直肠给予甘油、甘露醇和速尿时，脑脊液压力分别比初始水平下降35 - 45%、35 - 40%和20 - 25%，并且在整个观察期内均未升高。
