Sorel L, Rucquoy-Ponsar M, Willems C, Diepart E, Harmant J
Acta Neurol Belg. 1981 Sep-Oct;81(5):283-90.
The action of valproic acid prescribed instead of sodium valproate in strictly identical conditions was analysed in 11 epileptic children and 24 adults. No change in therapeutic effect was observed in a large proportion of cases. However, blood tests showed an increase in serum levels in most cases. Thus, valproic acid can be of help in cases hitherto treated with sodium valproate, on the same basis as diphenylhydantoin; the acid form sometimes offers an advantage over the use of the sodium salt.
在11名癫痫儿童和24名成人中分析了在完全相同的条件下用丙戊酸替代丙戊酸钠的作用。在大部分病例中未观察到治疗效果的变化。然而,血液检测显示在大多数病例中血清水平有所升高。因此,丙戊酸在迄今用丙戊酸钠治疗的病例中可能有用,与苯妥英钠的情况相同;酸形式有时比钠盐的使用具有优势。