Günöz H, Neyzł O, Sencer E, Molvalilar S, Argun A
Acta Paediatr Scand. 1981 Jul;70(4):521-6. doi: 10.1111/j.1651-2227.1981.tb05734.x.
Plasma hGH levels were assessed in 15 infants with protein energy malnutrition following insulin induced hypoglycemia, arginine and L-Dopa provocation tests and intravenous glucose tolerance test. Fasting hGH levels were high in 85.7% of the cases. An adequate hGH response to stimulation was obtained in only 42.8% of the cases with insulin induced hypoglycemia; in 52.5% with arginine; in 30.8% with L-Dopa. Response to at least one type of provocation was obtained in all 5 cases to which all three tests were applied. Exaggerated or delayed response to provocative stimuli was also encountered in a number of the cases. Intravenous glucose tolerance test did not lead to suppression in hGH secretion or to increase in insulin secretion in these subjects. The results indicate that marasmic protein energy malnutrition may lead to defects in the hGH secretory function of the hypothalamopituitary axis.
对15名蛋白质能量营养不良的婴儿进行了血浆生长激素（hGH）水平评估，评估方法包括胰岛素诱发低血糖试验、精氨酸和左旋多巴激发试验以及静脉葡萄糖耐量试验。85.7%的病例空腹hGH水平较高。胰岛素诱发低血糖试验中，仅有42.8%的病例对刺激有足够的hGH反应；精氨酸试验中为52.5%；左旋多巴试验中为30.8%。对所有5例进行了三项试验的病例，均对至少一种激发试验有反应。在一些病例中还出现了对激发刺激的反应过度或延迟。静脉葡萄糖耐量试验并未导致这些受试者的hGH分泌受抑制或胰岛素分泌增加。结果表明，消瘦型蛋白质能量营养不良可能导致下丘脑 - 垂体轴的hGH分泌功能缺陷。
