Arora R G
Acta Pathol Microbiol Scand A. 1981 Jul;89(4):303-8. doi: 10.1111/j.1699-0463.1981.tb00225.x.
Weanling male mice with or without prior treatment with CCl4 (0.5 ml/kg) were exposed to either single (20.5, 25.6, 32 and 40 mg/kg) or multiple (4 mg/kg for 10 days or 8 mg/kg for 5 days) doses of aflatoxin B1. Evidence of its acute toxic and carcinogenic effects was found only in CCl4 pre-treated mice. Single dose LD 50 value under these conditions was calculated to be 26.8 mg/kg. Histological changes which predominantly occurred in the liver were characterized by acute necrosis and degeneration of the parenchymal cells. Hepatomas were observed as early as 9 months of age in CCl4 pre-treated animals given 4 mg/kg aflatoxin daily for 10 days. It is thus suggested that the repeated use of CCl4 as an anthelmintic in animals which are apparently resistant to the lethal and hepatocarcinogenic action of aflatoxin might increase their sensitivity to this mycotoxin.
对断奶雄性小鼠进行或不进行四氯化碳（0.5毫升/千克）预处理后，分别给予单剂量（20.5、25.6、32和40毫克/千克）或多剂量（4毫克/千克，持续10天或8毫克/千克，持续5天）的黄曲霉毒素B1。仅在四氯化碳预处理的小鼠中发现了其急性毒性和致癌作用的证据。在这些条件下计算出的单剂量半数致死量值为26.8毫克/千克。主要发生在肝脏的组织学变化的特征是实质细胞的急性坏死和变性。在每天给予4毫克/千克黄曲霉毒素、持续10天的四氯化碳预处理动物中，早在9个月大时就观察到了肝癌。因此，有人提出，在对黄曲霉毒素的致死和肝癌致癌作用明显有抗性的动物中反复使用四氯化碳作为驱虫剂，可能会增加它们对这种霉菌毒素的敏感性。
