Freire F R, Nahoum C R
Andrologia. 1981 Sep-Oct;13(5):395-404. doi: 10.1111/j.1439-0272.1981.tb00071.x.
Steroidal and gonadotropic secretion were studied in infertile men with varicocele. Hormonal values were compared with those from control groups. No significant difference was found between control and pathologic groups in relation to prolactin secretion. FSH and LH showed increased basal values in 16% and 8% these cases in the group studies. Exaggerated gonadotropic response to LH-RH was observed in 33.3% of the patients. Basal testosterone and estradiol levels were found to be reduced in 18% and 30% of the cases, respectively. Testosterone response to LH-RH was also depressed in men with varicocele. Significant correlations were still observed between FSH and LH, LH and testosterone and testosterone and estradiol in infertile men with varicocele. These findings suggest both a tubular and interstitial involvement in varicocele and support the hypothesis of a Leydig cell deficiency in this pathology.
对患有精索静脉曲张的不育男性的甾体和促性腺激素分泌进行了研究。将激素值与对照组的值进行了比较。在催乳素分泌方面，对照组和病理组之间未发现显著差异。在分组研究中，这些病例中有16%的FSH和8%的LH基础值升高。在33.3%的患者中观察到对LH-RH的促性腺激素反应过度。分别在18%和30%的病例中发现基础睾酮和雌二醇水平降低。精索静脉曲张男性对LH-RH的睾酮反应也受到抑制。在患有精索静脉曲张的不育男性中，仍观察到FSH与LH、LH与睾酮以及睾酮与雌二醇之间存在显著相关性。这些发现表明精索静脉曲张同时累及曲细精管和间质，并支持了这种病理状态下存在睾丸间质细胞缺陷的假说。
