Konturek S J, Obtulowicz W, Kwiecien N, Sito E, Mikos E, Oleksy J
Gut. 1980 Mar;21(3):181-6. doi: 10.1136/gut.21.3.181.
The effects of ranitidine, a new H2-receptor antagonist which does not contain an imidazole ring, and cimetidine have been determined on histamine, meal-induced gastric acid secretion, and serum gastrin levels in duodenal ulcer patients. Compared with cimetidine, ranitidine was found to be about eight times more potent an inhibitor of histamine-induced secretion and four to five times more potent an inhibitor of sham-feeding, and real feeding induced acid secretion without effecting serum gastrin levels.
已测定新型不含咪唑环的H2受体拮抗剂雷尼替丁和西咪替丁对十二指肠溃疡患者组胺、进餐诱导的胃酸分泌及血清胃泌素水平的影响。与西咪替丁相比,雷尼替丁对组胺诱导分泌的抑制作用约强八倍,对假饲及实际进食诱导的胃酸分泌的抑制作用强四至五倍,且不影响血清胃泌素水平。