Krekmanov L
Int J Oral Surg. 1981 Jun;10(3):173-9. doi: 10.1016/s0300-9785(81)80051-8.
The aim of the investigation was to assess the importance of various factors in the aetiology of alveolitis sicca dolorosa. Two hundren partially erupted or totally impacted mandibular third molars were surgically removed. The patients were divided into four groups. The patients in group 1 were premedicated with a single dose of penicillin-V (phenoxymethylpenicillin), those in group 2 with an antisialogogue (methylscopolamine nitrate), and those in group 3 with an antifibrinolytic agent (tranexamic acid). Group 4 were non-premedicated controls. The frequency of alveolitis in the groups 1 and 2 was significantly less than in the groups 3 and 4. This indicates the importance of salivary contamination of the surgical field and of infection as aetiologic factors in alveolitis.
本研究的目的是评估各种因素在干性疼痛性牙槽炎病因学中的重要性。通过手术拔除了200颗部分萌出或完全阻生的下颌第三磨牙。患者被分为四组。第1组患者术前给予单剂量青霉素V（苯氧甲基青霉素），第2组给予抗唾液分泌剂（硝酸甲基东莨菪碱），第3组给予抗纤维蛋白溶解剂（氨甲环酸）。第4组为未进行术前用药的对照组。第1组和第2组牙槽炎的发生率明显低于第3组和第4组。这表明手术区域唾液污染和感染作为牙槽炎病因学因素的重要性。
