Mills B G
J Oral Pathol. 1981 Jun;10(3):203-15. doi: 10.1111/j.1600-0714.1981.tb01266.x.
Distinction between lesions of the jaws containing giant cells can be difficult. This study reports the results of the study of the ultrastructure of 30 patients with Paget's disease in comparison with a patient diagnosed as having malignant giant cell tumor of the mandible. The ultrastructure of the malignant giant cell tumor of the mandible was found to contain nuclear inclusions morphologically identical with the 12-15 nm tubules characteristic of the nuclei of osteoclasts in Paget's disease of bone. No clinical or laboratory signs of Paget's disease was found in this patient. A search of the literature failed to produce reports of identical nuclear inclusions in soft tissue giant cell tumors, osteosarcomas, reparative granulomas containing giant cells or in osteitis fibrosa cystica. Such nuclear inclusions have been reported in benign giant cell tumors of bone, one another in malignant giant cell tumor and cases of polymyositis. These observations raise the question of a possible virus associated with the tumor since there are recent reports of immunological evidence for the presence of a virus in Paget's disease, and viruses have been suspected in polymyositis.
区分含巨细胞的颌骨病变可能很困难。本研究报告了30例佩吉特病患者的超微结构研究结果，并与1例被诊断为下颌骨恶性巨细胞瘤的患者进行了比较。发现下颌骨恶性巨细胞瘤的超微结构中含有核内包涵体，其形态与骨佩吉特病中破骨细胞核特有的12 - 15纳米小管相同。该患者未发现佩吉特病的临床或实验室体征。检索文献未发现软组织巨细胞瘤、骨肉瘤、含巨细胞的修复性肉芽肿或纤维囊性骨炎中存在相同核内包涵体的报道。这种核内包涵体已在骨良性巨细胞瘤、恶性巨细胞瘤及多发性肌炎病例中被报道。这些观察结果提出了一个问题，即可能存在与该肿瘤相关的病毒，因为最近有报道称有免疫学证据表明佩吉特病中存在病毒，且多发性肌炎中也怀疑有病毒。
